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Man Chen Selected Research

Neuroprotective Agents

12/2023TREM2-IGF1 Mediated Glucometabolic Enhancement Underlies Microglial Neuroprotective Properties During Ischemic Stroke.
4/2023TREM2 deficiency inhibits microglial activation and aggravates demyelinating injury in neuromyelitis optica spectrum disorder.
5/2019Ghrelin Promotes Cortical Neurites Growth in Late Stage After Oxygen-Glucose Deprivation/Reperfusion Injury.
7/2013CART attenuates endoplasmic reticulum stress response induced by cerebral ischemia and reperfusion through upregulating BDNF synthesis and secretion.

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Man Chen Research Topics

Disease

19Infections
12/2022 - 11/2007
18Neoplasms (Cancer)
04/2024 - 05/2014
10Demyelinating Diseases (Demyelinating Disease)
04/2024 - 11/2020
9Hypoxia (Hypoxemia)
02/2022 - 08/2010
8Neuromyelitis Optica (Devic's Disease)
01/2024 - 10/2019
8Breast Neoplasms (Breast Cancer)
09/2022 - 06/2012
7Inflammation (Inflammations)
03/2024 - 08/2012
7Ischemic Stroke
12/2023 - 10/2019
6COVID-19
11/2023 - 01/2020
6Stroke (Strokes)
09/2022 - 01/2019
6Respiratory Syncytial Virus Infections
01/2018 - 05/2009
5Neuroinflammatory Diseases
03/2024 - 03/2021
5Ischemia
02/2020 - 08/2010
5Fetal Growth Retardation (Intrauterine Growth Retardation)
12/2011 - 11/2007
4Multiple Sclerosis
05/2023 - 07/2003
4Hepatocellular Carcinoma (Hepatoma)
01/2023 - 04/2015
4Reperfusion Injury
05/2019 - 08/2010
4Human Influenza (Influenza)
01/2019 - 10/2012
4Hepatitis B
02/2014 - 01/2011
3Sepsis (Septicemia)
02/2023 - 01/2016
3Hemorrhage
11/2022 - 01/2002
3Neoplasm Metastasis (Metastasis)
01/2022 - 04/2015
3Pneumonia (Pneumonitis)
12/2021 - 05/2009
2Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
03/2024 - 01/2022
2Acute Kidney Injury (Acute Renal Failure)
02/2024 - 12/2023
2Residual Neoplasm
07/2023 - 01/2023
2Fibrosis (Cirrhosis)
01/2023 - 01/2006
2Hyperthermia
11/2021 - 09/2021
2Brain Injuries (Brain Injury)
11/2021 - 01/2019
2Obesity
11/2021 - 03/2021
2Brain Ischemia (Cerebral Ischemia)
05/2019 - 07/2013
2Stomach Neoplasms (Stomach Cancer)
03/2018 - 01/2018
2Fetal Hypoxia
05/2013 - 08/2010
2Liver Cirrhosis (Hepatic Cirrhosis)
04/2010 - 03/2008

Drug/Important Bio-Agent (IBA)

15VaccinesIBA
01/2024 - 11/2004
13Proteins (Proteins, Gene)FDA Link
11/2023 - 08/2010
12Biomarkers (Surrogate Marker)IBA
01/2024 - 10/2013
10EpitopesIBA
12/2022 - 10/2010
7AntibodiesIBA
11/2023 - 01/2016
6Messenger RNA (mRNA)IBA
08/2023 - 01/2006
6DNA (Deoxyribonucleic Acid)IBA
07/2023 - 10/2011
6Neutralizing AntibodiesIBA
01/2019 - 03/2014
5Therapeutic UsesIBA
01/2024 - 11/2003
4Neuroprotective AgentsIBA
12/2023 - 07/2013
4Monoclonal AntibodiesIBA
11/2023 - 02/2010
4Reactive Oxygen Species (Oxygen Radicals)IBA
12/2022 - 11/2017
4Glucose (Dextrose)FDA LinkGeneric
09/2022 - 07/2013
4SteroidsIBA
01/2022 - 07/2015
4Immunoglobulin G (IgG)IBA
01/2022 - 07/2013
4Ethanol (Ethyl Alcohol)IBA
01/2018 - 01/2006
4CytokinesIBA
12/2017 - 07/2003
4DecitabineFDA Link
01/2017 - 08/2010
4NicotineFDA Link
12/2011 - 11/2007
3LipidsIBA
01/2024 - 01/2020
3Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
02/2020 - 05/2014
3Oxygen (Dioxygen)IBA
05/2019 - 07/2013
3Glycoproteins (Glycoprotein)IBA
01/2017 - 01/2016
3AntigensIBA
01/2017 - 07/2003
3Estrogen ReceptorsIBA
07/2015 - 09/2012
2oxidized low density lipoproteinIBA
04/2024 - 01/2024
2Fluorescent Dyes (Fluorescent Probes)IBA
04/2024 - 05/2023
2Mitochondrial DNA (mtDNA)IBA
04/2024 - 07/2015
2Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA
03/2024 - 01/2022
2Bile Acids and Salts (Bile Acids)IBA
01/2024 - 01/2018
2AlbuminsIBA
12/2023 - 02/2020
2RNA (Ribonucleic Acid)IBA
07/2023 - 01/2023
2NAD (NADH)IBA
05/2023 - 11/2021
2Complement System Proteins (Complement)IBA
04/2023 - 10/2019
2Lysophosphatidylcholines (Lysophosphatidylcholine)IBA
11/2022 - 11/2020
216S Ribosomal RNAIBA
10/2022 - 06/2020
2Myelin-Oligodendrocyte GlycoproteinIBA
10/2022 - 11/2020
2AutoantibodiesIBA
10/2022 - 09/2021
2Peptides (Polypeptides)IBA
04/2022 - 07/2003
2Antiviral Agents (Antivirals)IBA
01/2022 - 01/2017
2Fingolimod Hydrochloride (FTY720)FDA Link
03/2021 - 01/2021
2Phosphotransferases (Kinase)IBA
08/2020 - 07/2013
2acyl-ghrelinIBA
05/2019 - 01/2019
2Cisplatin (Platino)FDA LinkGeneric
03/2018 - 11/2017
2InterferonsIBA
01/2017 - 02/2012
2PalivizumabFDA Link
01/2017 - 02/2010
2Respiratory Syncytial Virus VaccinesIBA
12/2016 - 05/2009
2Small Interfering RNA (siRNA)IBA
01/2016 - 07/2013
2Estrogens (Estrogen)FDA Link
07/2015 - 09/2012
2HMGB1 Protein (HMG1)IBA
07/2015 - 04/2015
2Protein Kinase C-epsilonIBA
01/2011 - 08/2010
2Verapamil (Calan)FDA LinkGeneric
04/2010 - 03/2008
2Cytochrome P-450 CYP1A1 (CYP1A1)IBA
02/2009 - 01/2006
2Member 1 Subfamily B ATP Binding Cassette TransporterIBA
02/2009 - 03/2008
2Carbon Tetrachloride (Tetrachloromethane)IBA
03/2008 - 01/2006
2Cytochrome P-450 CYP3AIBA
03/2008 - 01/2006
2Ofloxacin (Ofloxacine)FDA LinkGeneric
11/2007 - 01/2006

Therapy/Procedure

14Therapeutics
12/2023 - 05/2009
5Neoadjuvant Therapy
11/2023 - 09/2016
4Immunotherapy
01/2024 - 04/2021
4Thrombectomy
10/2022 - 09/2021
3Drug Therapy (Chemotherapy)
11/2023 - 06/2012
2Renal Replacement Therapy (Therapies, Renal Replacement)
02/2024 - 12/2023
2Artificial Respiration (Mechanical Ventilation)
12/2023 - 01/2020
2Traditional Medicine (Folk Remedies)
03/2021 - 10/2012
2Oral Administration
03/2008 - 01/2006